肌球蛋白轻链激酶

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中医宝典 > 肌球蛋白轻链激酶
肌球蛋白轻多肽激酶，平滑肌
识别
符号MYLK
Entrez4638
HUGO7590
OMIM600922
RefSeqNM_053025
UniProtQ15746
其他资料
EC编号2.7.11.18
基因座3 qcen-q21
myosin light-chain kinase 2, skeletal muscle
SkMLCK.png
Crystal structure of the S. dubia centrin / human skeletal muscle myosin light-chain complex.[1]
识别
符号MYLK2
Entrez85366
HUGO16243
OMIM606566
RefSeqNM_033118
UniProtQ9H1R3
其他资料
基因座20 q13.31
myosin light-chain kinase 3, cardiac
识别
符号MYLK3
Entrez91807
HUGO29826
OMIM612147
RefSeqNM_182493
UniProtQ32MK0
其他资料
基因座16 q11.2
人类肌球蛋白轻链激酶
2X4F.pdb.png
The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.[2]
识别
符号MYLK4
Entrez340156
HUGO27972
RefSeqNM_001012418
UniProtQ86YV6
其他资料

肌球蛋白轻链激酶（英语：Myosin light-chain kinase，MYLK 或 MLCK）是一类丝氨酸/苏氨酸特异性蛋白激酶，通过磷酸化来调节II型肌球蛋白的轻链[3]。

目录

  1. 亚型
  2. 功能
  3. 另见
  4. 参考文献
  5. 延伸阅读
  6. 外部链接
  7. 参考来源

亚型

现存四种MLCK亚型[4]主要分布于不同肌细胞：

  • MYLK – 平滑肌
  • MYLK2 – 骨骼肌
  • MYLK3 – 心肌
  • MYLK4 – 未知

功能

另见

  • 蛋白激酶A

参考文献

  1. ↑ RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex. 
  2. ↑ RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.. 
  3. ↑ Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K. Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction. IUBMB Life. June 2001, 51 (6): 337–44. doi:10.1080/152165401753366087. PMID 11758800. 
  4. ↑ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. December 2002, 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243. 

延伸阅读

  • Strausberg RL, Feingold EA, Grouse LH, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/ Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.]. Proc. Natl. Acad. Sci. U.S.A.. 2003, 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. PMC 139241. 
  • Gerhard DS, Wagner L, Feingold EA, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/ The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).]. Genome Res.. 2004, 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. PMC 528928. 
  • Clayburgh DR, Rosen S, Witkowski ED, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1237105/ A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.]. J. Biol. Chem.. 2005, 279 (53): 55506–13. doi:10.1074/jbc.M408822200. PMID 15507455. PMC 1237105. 
  • Wang F, Graham WV, Wang Y, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1237049/ Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.]. Am. J. Pathol.. 2005, 166 (2): 409–19. doi:10.1016/S0002-9440(10)62264-X. PMID 15681825. PMC 1237049. 
  • Russo JM, Florian P, Shen L, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1237051/ Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.]. Gastroenterology. 2005, 128 (4): 987–1001. doi:10.1053/j.gastro.2005.01.004. PMID 15825080. PMC 1237051. 
  • Shimizu S, Yoshida T, Wakamori M, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1464317/ Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.]. J. Physiol. (Lond.). 2006, 570 (Pt 2): 219–35. doi:10.1113/jphysiol.2005.097998. PMID 16284075. PMC 1464317. 
  • Kim MT, Kim BJ, Lee JH, et al.. Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.. Am. J. Physiol., Cell Physiol.. 2006, 290 (4): C1031–40. doi:10.1152/ajpcell.00602.2004. PMID 16306123. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129/ Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.]. Genome Res.. 2006, 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. PMC 1356129. 
  • Connell LE, Helfman DM. Myosin light chain kinase plays a role in the regulation of epithelial cell survival.. J. Cell. Sci.. 2007, 119 (Pt 11): 2269–81. doi:10.1242/jcs.02926. PMID 16723733. 
  • Seguchi O, Takashima S, Yamazaki S, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1978424/ A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.]. J. Clin. Invest.. 2007, 117 (10): 2812–24. doi:10.1172/JCI30804. PMID 17885681. PMC 1978424. 

外部链接


肌球蛋白轻链激酶引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。

参考来源